The game's LOD.config file is used to store many game options such as resolution, controllers etc. If this file is missing, the game will create a new one with default values.
If you feel that you have config related issues (e.g. unexplained crashes, glitches after changing game options), then you can try deleting this file so a new one can be created by the game.
Quit to Windows
Locate (see valid locations below) and delete the LOD.config file
Restart the game
Depending on your game version and installation (x86, x64) the game's config file can be located in one of the following locations.
e.g
C:\Program Files (x86)\Steam\SteamApps\common\Line of Defense\
C:\Program Files\Steam\SteamApps\common\Line of Defense\